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CARE Network Publications

2011

Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Fernando Martinez, M.D., Vernon M. Chinchilli, Ph.D., Wayne J. Morgan, M.D., Susan J. Boehmer, M.A., Robert F. Lemanske Jr, M.D., David T. Mauger, Ph.D., Robert C. Strunk, M.D Stanley J. Szefler, M.D., Robert S. Zeiger, M.D., Ph.D., Leonard B. Bacharier, M.D., Elizabeth Bade, M.D., Ronina A. Covar, M.D., Noah J. Friedman, M.D., Theresa W. Guilbert, M.D., Hengameh Heidarian-Raissy, Pharm.D., H. William Kelly, Pharm.D., Jonathan Malka-Rais, M.D., Michael H. Mellon, M.D., Christine A. Sorkness, Pharm.D., Lynn Taussig, M.D. for the Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. The LANCET, Vol. 377, Issue 9766, Pages 650-657.

Cost-Effectiveness Analysis of Fluticasone vs. Montelukast in Children with Mild-moderate Persistent Asthma in the Pediatric Asthma Controller Trial. Li Wang, Chris Hollenbeak, Dave Mauger, Chris Sorkness, Robert Zeiger, Ian Paul, Rob Lemanske, Fernando Martinez, Robert Strunk, Stan Szefler, Lynn Taussig for the Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute.  The Journal of Allergy and Clinical Immunology, Vol. 127, Issue 1, Pages 161-166.e1.

2010

Urinary Leukotriene E4/Exhaled Nitric Oxide Ratio and Montelukast Response in Childhood Asthma. Nathan Rabinovitch, MD, Nora J Graber, MS, Vernon M. Chinchilli, PhD, Christine A. Sorkness, PharmD, Robert S. Zeiger MD, PhD, Robert C Strunk, MD, Leonard B. Bacharier, Fernando D. Martinez, MD, Stanley J. Szefler, MD. for the Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute.  The Journal of Allergy and Clinical Immunology, Vol. 126, Issue 3, Pages 545-551,e4.7/8/10.

Forced expiratory flow between 25% and 75% of vital capacity and FEV1/forced vital capacity ratio in relation to Clinical  and physiologic parameters in asthmatic children with normal FEV1 Values. Michael R Simon, MD, Vernon Chinchilli, PhD, Brenda R. Phillips, MS, Chris Sorkness, PharmD, Robert Lemanske, Jr., MD, Stanley J. Szefler, MD, Lynn Taussig, MD, Leonard Bacharier, MD, Wayne Morgan, MD, for the Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute.  The Journal of Allergy and Clinical Immunology. Vol. 126, issue 3, pages 527-534.e8.

Step-up Therapy for Children with Uncontrolled Asthma while Receiving Inhaled Corticosteroids. Robert F. Lemanske, Jr., M.D., David T. Mauger, Ph.D., Christine A. Sorkness, Pharm.D., Daniel J. Jackson, M.D., Susan J. Boehmer, M.S., Fernando D. Martinez, M.D., Robert C. Strunk, M.D., Stanley J. Szefler, M.D., Robert S. Zeiger, M.D., Ph.D., Leonard B. Bacharier, M.D., Ronina A. Covar, M.D., Theresa W. Guilbert, M.D., Gary Larsen, M.D., Wayne J. Morgan, M.D., Mark H. Moss, M.D., Joseph D. Spahn, M.D., and Lynn M. Taussig, M.D., for the Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute.  Published Online March 2, 2010 (DOI: 10.1056/NEJMoa1001278).

Relationship Between Infant Weight Gain and Later Asthma.  Paul IM, Camera L, Zeiger RS, Guilbert TW, Bacharier LB, Taussig LM, Morgan WJ, Covar RA, Krawiec M, Bloomberg GR, Mauger DT. Pediatric Allergy and Immunology 2010: 21: 82-89.

2009

Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma. J. Knuffman, C. Sorkness, R. Lemanske Jr., D. Mauger, S. Boehmer, F. Martinez, L. Bacharier, R. Strunk, S. Szefler, R. Zeiger Taussig, L. and the Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Journal of Allergy and Clinical Immunology. (2009) Volume 123, Issue 2, Pages 411-416

Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma. Gary L. Larsen, Wayne Morgan, Gregory P. Heldt, David T. Mauger, Susan J. Boehmer, Vernon M. Chinchilli, Robert F. Lemanske Jr., Fernando Martinez, Robert C. Strunk, Stanley J. Szefler, Robert S. Zeiger, Lynn M. Taussig, Leonard B. Bacharier, Theresa W. Guilbert, Shelley Radford, Christine A. Sorkness and Childhood Asthma Research and Education Network of the National Heart Lung, and Blood Institute.  Journal of Allergy and Clinical Immunology, April 2009, Volume 123, Issue 4, pgs. 861-867.

Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma. Leonard B. Bacharier, Theresa W. Guilbert, Robert S. Zeiger, Robert C. Strunk, Wayne J. Morgan, Robert F. Lemanske, Mark Moss, Stanley J. Szefler, Marzena Krawiec, Susan Boehmer, David Mauger, Lynn M. Taussig, Fernando D. Martinez, Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. The Journal of Allergy and Clinical Immunology, May 2009, Volume 123, issue 5, pgs.1077-1082.e5.

Signs and Symptoms that Precede Wheezing in Children with Moderate to Severe Intermittent Wheezing. Kathy Rivera-Spoljaric, Vernon M. Chinchilli, Lindsay J. Camera, Robert S. Zeiger, Ian M. Paul, Brenda R. Phillips, Lynn M. Taussig, Robert C. Strunk, Leonard B. Bacharier, Childhood Asthma Research and Education (CARE) Network. The Journal of Pediatrics, June, 2009, Volume 154, Issue 6, pages 877-881.e4.

Elevated Exhaled Nitric oxide Levels Increasae Risk of Respiratory Tract Illness in Preschool Children with Moderate to Severe Intermittent Wheezing. A. Beigelman, L. Bacharier, D. Mauger, B. Phillips, R. Zeiger, L. Taussig, R. Strunk. Annals of Allergy, Asthma, & Immunology, Vol. 103, No. 2, August 2009, pp.108-113.

2008

Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. Bacharier LB, Phillips BR, Zeiger RS, Szefler SJ, Martinez FD, Lemanske RF Jr, Sorkness CA, Bloomberg GR, Morgan WJ, Paul IM, Guilbert T, Krawiec M, Covar R, Larsen G, Mellon M, Moss MH, Chinchilli VM, Taussig LM, Strunk RC; CARE Network.  J Allergy Clin Immunol. (2008) Dec;122:6:1127-1135.e8

Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children. Ronina A. Covar, MD,a Stanley J. Szefler, MD,a Robert S. Zeiger, MD, PhD,b Christine A. Sorkness, PharmD,c Mark Moss, MD,c David T. Mauger, PhD,d Susan J. Boehmer, PhD,d Robert C. Strunk, MD,e Fernando D. Martinez, MD,f and Lynn M. Taussig, MD,a for the Childhood Asthma Research and Education Network Denver, Colo, San Diego, Calif, Madison, Wis, Tucson, Ariz, St Louis, Mo, and Hershey, Pa. American Academy of Allergy, Asthma & Immunology (2008); 122:4:741-747.e4

Azithromycin or montelukast as inhaled corticosteroid–sparing agents in moderate-to- severe childhood asthma study. Robert C. Strunk, MD, Leonard B. Bacharier, MD, Brenda R. Phillips, MS, Stanley J. Szefler, MD,Robert S. Zeiger, MD, PhD, Vernon M. Chinchilli, PhD, Fernando D. Martinez, MD, Robert F. Lemanske, Jr, MD, Lynn M. Taussig, MD, David T. Mauger, PhD, Wayne J. Morgan, MD, Christine A. Sorkness, PharmD, Ian M. Paul, MD, Theresa Guilbert, MD, Marzena Krawiec, MD, Ronina Covar, MD, Gary Larsen, MD, and the Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute.  American Academy of Allergy, Asthma & Immunology (2008); 122:6:1138-1144.e4

2007

Severe intermittent wheezing in preschool children: A distinct phenotype. Bacharier LB, Phillips BR, Bloomberg GR, Zeiger RS, Paul IM, Krawiec M, Guilbert T, Chinchilli VM, Strunk RC, for the Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute.  Journal of Allergy and Clinical Immunology (2007); 119: 604-610.

Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: The Pediatric Asthma Controller Trial. Christine A. Sorkness, PharmD, Robert F. Lemanske, Jr, MD, David T. Mauger, PhD, Susan J. Boehmer, MA, Vernon M. Chinchilli, PhD, Fernando D. Martinez, MD, Robert C. Strunk, MD, Stanley J. Szefler, MD, Robert S. Zeiger, MD, PhD, Leonard B. Bacharier, MD, Gordon R. Bloomberg, MD, Ronina A. Covar, MD, Theresa W. Guilbert, MD, Gregory Heldt, MD, Gary Larsen, MD, Michael H. Mellon, MD, Wayne J. Morgan, MD, Mark H. Moss, MD, Joseph D. Spahn, MD, and Lynn M. Taussig, MD.   J Allergy Clin Immunol (2007);119:64-72.

2006

Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma. Zeiger RS, Szefler SJ, Phillips BR, Schatz M, Martinez FD, Chinchilli VM, Lemanske RF, Strunk RC, Larsen G, Spahn JD, Bacharier LB, Bloomberg GR, Guilbert TW, Heldt G, Morgan WJ, Moss MH, Sorkness CA, Taussig LM.  J Allergy Clin Immunol (2006); 117:1:45-52.

Long-Term Inhaled Corticosteroids in Preschool Children at High Risk for Asthma. Theresa W. Guilbert, M.D., Wayne J. Morgan, M.D., Robert S. Zeiger, M.D., Ph.D., David T. Mauger, Ph.D., Susan J. Boehmer, M.A., Stanley J. Szefler, M.D., Ph.D., Leonard B. Bacharier, M.D., Robert F. Lemanske, Jr., M.D., Robert C. Strunk, M.D., David B. Allen, M.D., Gordon R. Bloomberg, M.D., Gregory Heldt, M.D., Marzena Krawiec, M.D., Gary Larsen, M.D., Andrew H. Liu, M.D., Vernon M. Chinchilli, Ph.D., Christine A. Sorkness, Pharm.D., Lynn M. Taussig, M.D., and Fernando D. Martinez, M.D.   N Engl J Med (2006); 354:19:1985-1997.

2005

Characterization of Within-Subject Responses to Fluticasone and Montelukast in Childhood Asthma. Szefler SJ, Phillips B, Martinez FD, Chinchilli VM, Lemanske RF, Strunk RC, Zeiger RS, Larsen G, Spahn JD, Bacharier LB, Bloomberg GR, Guilbert TW, Heldt G, Morgan WJ, Moss MH, Sorkness CA, Taussig LM.   J Allergy Clin Immunol (2005); 115:233-242.

Web-based distributed data management in the Childhood Asthma Research and Education (CARE) Network. Schmidt JR, Vignati AJ, Pogash RM, Simmons VA, Evans RL. Clinical Trials (2005); 2:50-60

A General Class of Correlation Coefficients for the 2 X 2 Crossover Design. Chinchilli VM, Phillips BR, Mauger DT, Szefler, SJ. Biometrical Journal (2005); 47:5:644-653.

2004

The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network. Guilbert TW, Morgan WJ, Krawiec M, Lemanske RF Jr, Sorkness C, Szefler SJ, Larsen G, Spahn JD, Zeiger RS, Heldt G, Strunk RC, Bacharier LB, Bloomberg GR, Chinchilli VM, Boehmer SJ, Mauger EA, Mauger DT, Taussig LM, Martinez FD.  Control Clin Trials. (2004); 25:286-310.

Classifying Asthma Severity in Children-Mismatch Between Symptoms, Medication Use and Lung Function. Bacharier LB, Strunk RC, Mauger D, White D, Lemanske RF, Sorkness CA. Am J Repir Crit Care Med. (2004); 170:426-432.

Atopic Characteristics of Children with Recurrent Wheezing at high risk for the development of childhood asthma. Guilbert TW, Morgan WJ, Zeiger RS, Bacharier L, Boehmer SJ, Krawiec M, Larsen G, Lemanske RF, Liu A, Mauger DT, Sorkness C, Szefler SJ, Strunk RC, Taussig L, Martinez F.  J Allergy Clin Immunol (2004); 114:1282-1287.

2003

Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. Strunk RC, Szefler SJ, Phillips BR, Zeiger RS, Chinchilli VM, Larsen G, Hodgdon K, Morgan W, Sorkness CA, Lemanske RF Jr.   J. Allergy Clin Immunol (2003); 112:883-892.                                 

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